Write about Kartagener's Syndrome here.
• (Immotile cilia)
• Combination of bronchiectasis, sinusitis, male infertility + situs inversus (transposed heart and abdominal organs)
• Otitis media and salpingitis are frequent
• Results form defects in cilia function (including sperm), which also causes faulty foetal organ rotation
• ECG: Inverted P-waves in lead I, reversed R-wave progression
• Genetic defects in dyneins may have a role
• Large multisubunit ATPases interact with microtubules to generate cilia movement