Write about Kartagener's Syndrome here.

• (Immotile cilia)

• Combination of bronchiectasis, sinusitis, male infertility + situs inversus (transposed heart and abdominal organs)

• Otitis media and salpingitis are frequent

• Results form defects in cilia function (including sperm), which also causes faulty foetal organ rotation

Tests:

• ECG: Inverted P-waves in lead I, reversed R-wave progression

• Genetic defects in dyneins may have a role

• Large multisubunit ATPases interact with microtubules to generate cilia movement