International Prognostic Index

Age >60

Serum lactate dehydrogenase concentration above normal

ECOG performance status 2

Ann Arbor stage III or IV

Number of extranodal disease sites >1

One point is given for each of the above characteristics present in the patient, for a total score ranging from zero to five. When applied to the initial group of 2031 patients with aggressive NHL, five-year overall survival (OS) and complete response (CR) rates according to score were as follows:

Score

Risk group

5-yr OS, percent

CR rate, percent

0 to 1

Low risk

73

87

2

Low-intermediate risk

51

67

3

High-intermediate risk

43

55

4 to 5

High risk

26

44

Age adjusted International Prognostic Index

For this score, all of the prognostic factors listed above, with the exception of age and number of extranodal sites, are given one point, for a score ranging from zero to three. When applied to the group of 761 patients >60 years of age, five-year OS and CR rates according to the adjusted score were as follows:

Score

Risk Group

5-yr OS, percent

CR rate, percent

0

Low risk

56

91

1

Low-intermediate risk

44

71

2

High-intermediate risk

37

56

3

High risk

21

36