Write about Churg-Strauss Syndrome here.

Syndrome consisting of:

• Asthma

• Eosinophilia

• Fever

• Accompanying vasculitis of various organs

Shares many features of Polyarteritis Nodosa (PAN)

• First phase is Asthma - may begin long before the vasculitis.  Early signs include nasal polyps and allergic rhinitis

• Second phase is Eosinopilia - up to 60%

• Third phase is vasculitis, involving the skin, lungs, nerves, kidneys and other organs.

• Nose - sinusitis and nasal polyps

• Lung

Pulmonary infiltrates (1/3 of patients)

Bleeding into the lungs

Diffuse interstitial lung disease (rarely)

• Skin

Rashes

Palpable purpura

Nodules

• Kidney - Biggest cause of death

Glomerulonephritis

Hypertension

• GI

Granuloma sometimes found in spleen

Abdominal pain

Malabsorption due to chronic infarction

• CVS - Second biggest cause of death

Vasculitis lesions in heart -> HF or MI

• CNS

Peripheral nerve involvement - mononeuritis multiplex

Sensorimotor polyneuropathy

Seizures

Hemiplegia

Psychoses